The human eye has several specialized tissues which direct, capture, and pre-process information to provide vision.
RNA-seq gene expression analyses have been used extensively, for example, to profile specific eye tissues and in large consortium studies, like the GTEx project,
to study tissue-specific gene expression patterning.
However, there has not been an integrated study of multiple eye tissues expression patterning with other human
We have collated publicly available (deposited between January 1st, 2019 and November 1st, 2023) healthy human RNA-seq datasets and a substantial subset of the GTEx project RNA-seq datasets and processed
all of these samples in a consistent bioinformatic workflow. We use this fully integrated dataset to build informative visualizations, a novel PCA tool, and UCSC genome browser to provide the ophthalmic community with a powerful and quick means to formulate and test hypotheses on human
gene and transcript expression.
We make these data, analyses, and visualizations available here with a powerful interactive web application.